TRIAZOLE DERIVATIVES Russian patent published in 2011 - IPC C07D249/12 C07D401/12 C07D403/12 A61K31/4196 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula I, where R¹ -OH, R²- CONAA', SO₂NAA', SO₂NA-benzyl, SO₂NHAr, SO₂NAHet, SO₂NHA or S(O)mHet, R³, R⁵, R⁶ - H, R⁴ - H, Hal or A, Y - OH, A, A' denotes a straight or branched C1-C10 alkyl, in which one CH₂ group can be substituted with NR⁸, where R⁸ denotes a straight or branched C1-C6 alkyl or cycloalkyl, Ar denotes phenyl, Het denotes a saturated C5-C6-heterocyclic ring containing 1-2 nitrogen atoms, which can be substituted with A, m equals 1 or 2, and pharmaceutically suitable salts or tautomers thereof. The invention also relates to a method of producing said compounds and pharmaceutically suitable salts or tautomers thereof. The invention also relates to use of said compounds, salts or tautomers to prepare a medicinal agent for treating and/or preventing diseases affected by HSPS90 inhibition, as well as a medicinal agent based on said active ingredients, having HSP90 inhibiting activity. The invention also relates to an intermediate compound of formula I-1, where Z denotes A, Y - OH, R¹ - OCH₃, R² - SO₂Het, SO₂NHAr or SO₂NAA', R³ - H, R⁴ - Hal or A, R⁵, R⁶ - H, Ar - phenyl, Het - saturated C5-C6-heterocyclic ring, containing 1-2 nitrogen atoms which can be substituted with A, A, A' - straight or branched C1-C10 alkyl.

EFFECT: high efficiency of the composition.

6 cl, 1 tbl, 23 ex