FIELD: medicine, pharmaceutics.
SUBSTANCE: method of determining crystal structure of medication trimetazidine in form of tablets, which contains trimetazidine dihydrochloride, crystal filler and auxiliary substances, lies in the following: determination of crystal structure is carried out by difractometre DRON 3 with copper anticathode with irradiation λ=1.5405 E, voltage 40 kV and current intensity 40 mA for tablets with fixed dose of trimetazidine dihydrochloride 20 mg with application as crystal filler mannitol, for tablets with fixed dose of trimetazidine dihydrochloride 35 mg with application as crystal filler mannitol or calcium hydrophosphate dehydrate.
EFFECT: measured crystal structures can be used for control of production, prediction of active substance solubility and quality of medication tablets.
15 cl, 9 tbl
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