FIELD: medicine.
SUBSTANCE: invention relates to field of biotechnology, virology and medicine. Immunogenic composition includes virus-like particles (VLPs) HPV 16 and 18 and at least one of other oncogenic types of HPV, selected from the list which consists of types HPV 31, 45 and 52. Also described is vaccine for creation of immune response against human papilloma virus of types HPV16, HPV18 and at least one of types HPV31, HPV45 and HPV52, where dose of VLP of at least one of other oncogenic types is reduced relative to dose of HPV 16 or 18. Invention can be used in medicine.
EFFECT: obtaining vaccine for creation of immune response against human papilloma virus.
19 cl, 6 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| OPTIMISED EXPRESSION OF HPV 52 L1 IN YEAST | 2005 |
|
RU2373219C2 |
| HPV CHIMERIC PARTICLE | 2012 |
|
RU2642287C2 |
| NUCLEIC ACID MOLECULE ENCODING HPV 31 L1, EXPRESSION VECTOR, HOST CELL, VIRUS-LIKE PARTICLE AND METHOD OF ITS OBTAINMENT, VACCINE, PHARMACEUTICAL COMPOSITION AND METHODS INVOLVING THEM | 2004 |
|
RU2356943C2 |
| VACCINE COMPOSITION APPLICABLE IN HPV AND HEPATITIS VIRUS INFECTIONS, AND METHOD FOR PREPARING IT | 2009 |
|
RU2509570C2 |
| OPTIMISED EXPRESSION OF HPV 58 L1 IN YEAST | 2004 |
|
RU2370538C2 |
| RECOMBINANT VACCINE FOR PREVENTION OF HUMAN PAPILLOMAVIRUS INFECTION AND METHOD OF ITS PREPARATION | 2014 |
|
RU2546243C1 |
| METHOD OF OBTAINING A RECOMBINANT VACCINE FOR PREVENTION OF HUMANPAPILLOMA VIRUS INFECTION, RECOMBINANT VACCINE | 2018 |
|
RU2681174C1 |
| VACCINE COMPOSITIONS AGAINST HUMAN PAPILLOMA VIRUS (HPV), CONTAINING ALUMINIUM ADJUVANT, AND METHODS OF PRODUCTION THEREOF | 2012 |
|
RU2610174C2 |
| OPTIMISED EXPRESSION LI HPV45 IN YEAST | 2004 |
|
RU2360001C2 |
| FUNCTIONAL INFLUENZA VIRUS-LIKE PARTICLES (VLPs) | 2006 |
|
RU2483751C2 |
