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2 370 538

(13)

(51)

IPC

C12N15/33(2006-01-01)

C12N15/63(2006-01-01)

C12N5/10(2006-01-01)

C12N7/01(2006-01-01)

A61K39/12(2006-01-01)

A61P31/12(2006-01-01)

C07K14/25(2006-01-01)

(21) (22)

Application

2006120402/13, 2004-11-10

(24)

Start date

2004-11-10

(22)

Actual filing date

2004-11-10

(45)

Published

2009-10-20

(72)

Inventor

Brajan Dzhanin T.Braunlou Mishell K.Shul'Ts Loren D.Van Sin'-Min'Jansen Katrin U.

(73)

Holder

Merk Ehnd Ko., Ink.

OPTIMISED EXPRESSION OF HPV 58 L1 IN YEAST Russian patent published in 2009 - IPC C12N15/33 C12N15/63 C12N5/10 C12N7/01 A61K39/12 A61P31/12 C07K14/25

Abstract RU 2370538 C2

FIELD: medicine.

SUBSTANCE: invention claims synthetic DNS molecule encoding L1 HPV58 protein, where codons are optimised for high expression level in yeast cell. Also invention claims expression vector, yeast host cell, HPV58 virus-like particle and method of its obtainment, and pharmaceutical composition including such VLP.

EFFECT: invention can be applied in medicine for efficient immune prevention of papillomavirus infection by neutralising antibodies and cell-mediated immunity, and for treatment of developed HPV infections.

10 cl, 10 dwg, 8 ex

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RU 2 370 538 C2

Authors

Brajan Dzhanin T.

Braunlou Mishell K.

Shul'Ts Loren D.

Van Sin'-Min'

Jansen Katrin U.

Dates

2009-10-20—Published

2004-11-10—Filed