FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to medicine, namely to a new application of common indole derivatives for preparing a drug exhibiting the properties of a protein kinase C inhibitor. A preferential indole derivative is 1-methyl-2-phenylthiomethyl-3-carbethoxy-4-dimethylaminomethyl-5-oxy-6-bromindole hydrochloride.
EFFECT: compounds are effective protein kinase C inhibitors that allows them being used in treating inflammatory diseases, ischemia, cardiovascular diseases, dermatological diseases, asthma, diabetes.
3 cl, 3 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PHARMACEUTICAL COMPOSITION POSSESSING ANTIDIABETIC, HYPOLIPIDEMIC, HYPOGLYCEMIC AND CHOLESTEROL LOWERING ACTION, WAY OF ITS RECEPTION AND WAYS OF TREATMENT OF SPECIFIED DISEASES | 2007 |
|
RU2361581C2 |
| PROTEINKINASE C INHIBITORS USED FOR TREATING AUTOIMMUNE DISEASES AND GRAFT REJECTION | 2005 |
|
RU2413511C2 |
| PHARMACEUTICAL COMPOSITION EXHIBITING ANTI-INFLAMMATORY, PARTICULARLY ANTIASTHMATIC ACTION, APPLICATIONS OF PHARMACEUTICAL COMPOSITION (VERSIONS) AND DRUG (VERSIONS) | 2008 |
|
RU2406498C2 |
| TRIAZOLES USED AS PROTEIN KINASE INHIBITORS | 2005 |
|
RU2393155C2 |
| MEDICINAL AGENT BASED ON 4-SUBSTITUTED 3(3-DIALKYLAMINOMETHYL-INDOL-1-YL)MALEIMIDE DERIVATIVES | 2006 |
|
RU2388759C2 |
| GSK-3 INHIBITORS | 2006 |
|
RU2449998C2 |
| INDOLYLMALEIMIDE DERIVATIVES, METHOD OF THEIR OBTAINING, THEIR APPLICATION AND PHARMACEUICAL COMPOSITION FOR TREATMENT OR PREVENTION OF T-LYMPHOCYTE AND/OR "ПКС"- MEDIATED DISORDERS OR DISEASES | 2003 |
|
RU2340610C2 |
| PYRIMIDINE-SUBSTITUTED PURINE DERIVATIVES, PHARMACEUTICAL COMPOSITION BASED THEREON, METHOD OF PROTEIN KINASE INHIBITION, METHOD OF TREATING OR PREVENTING DISEASES SENSITIVE TO PROTEIN KINASE INHIBITION AND METHOD OF TREATING PROLIFERATIVE DISEASES | 2008 |
|
RU2518098C2 |
| SELECTIVE BUTYRYLCHOLIN ESTERASE INHIBITORS | 2005 |
|
RU2386627C2 |
| INDOLYLMALEIMIDE DERIVATIVES | 2005 |
|
RU2373201C2 |
