FIELD: chemistry.
SUBSTANCE: novel 1,2,4-triazole derivatives - protein kinase inhibitors of formula (I) 
are described, where X - N; Y - CH2, NH, NR or 0; R1 and R2 each independently denote hydrogen; R3 is phenyl, substituted with -CN, 6-member heteroaryl containing 1-2 N atoms, possibly substituted with a 7-member heterocyclyl containing 2 nitrogen atoms, which in turn is substituted with C1-6alkylcarbonyl; R4 is hydrogen; R5 is hydrogen or -CN; and R is a C1-6alkyl group, C1-6alkylcarbonyl group substituted with -CN, or a C3-6cycloalkyl group, a method of inhibiting FLT-3 or c-KIT protein kinase.
EFFECT: obtaining novel compounds and their use in making a medicinal agent for treating or relieving acute myelogenic leucosis.
11 cl, 1 tbl, 13 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DIAMINOTRIAZOLES, SUITABLE AS INHIBITORS OF PROTEIN KINASES | 2003 |
|
RU2350606C2 |
| PYRROLOPYRIMIDINES USED AS PROTEIN KINASE INHIBITORS | 2006 |
|
RU2434871C2 |
| ERK2 HETEROCYCLIC INHIBITORS AND THEIR USING | 2002 |
|
RU2300377C2 |
| BENZIMIDAZOLES USED AS PROTEIN KINASE INHIBITORS | 2006 |
|
RU2415853C2 |
| PYRAZOLO[1,5-a]PYRIMIDINES, USED AS PROTEIN KINASE INHIBITORS | 2005 |
|
RU2417996C2 |
| PYRAZOLE DERIVATIVES APPLIED AS PROTEIN KINASE INHIBITORS | 2001 |
|
RU2340611C2 |
| COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | 2007 |
|
RU2470012C2 |
| DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASE | 2007 |
|
RU2475488C2 |
| 2-UREIDO-6-HETEROARYL-3N-BENZIMIDAZOLE-6-CARBOXYLIC ACID DERIVATIVES AND RELATED COMPOUNDS AS GYRASE AND/OR TOPOISOMERASE INHIBITORS FOR BACTERIAL INFECTION TREATMENT | 2003 |
|
RU2333208C2 |
| PYRROLOPYRIDINES EFFECTIVE AS PROTEINKINASE INHIBITORS | 2006 |
|
RU2435769C2 |
