FIELD: chemistry.
SUBSTANCE: method enables to obtain 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one of formula (IV), which is a strong inhibitor of NS5B polymerase of hepatitis C virus (HCV).
EFFECT: high yield.
2 cl, 4 ex
Title | Year | Author | Number |
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ALKYL2-{[(2R,3S,5R)-5-(4-AMINO-2-OXO-2H-PYRIMIDINE-1-YL)- -HYDROXY- TETRAHYDRO-FURAN-2-YLMETHOXY]-PHENOXY-PHOSPHORYLAMINO}-PROPTONATES, NUCLEOSIDE INHIBITORS OF RNA-POLYMERASE HCV NS5B, METHODS FOR PRODUCING AND USING THEM | 2013 |
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Authors
Dates
2011-06-20—Published
2007-10-05—Filed