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2 422 157

(13)

(51)

IPC

A61K39/395(2006-01-01)

C12N15/63(2006-01-01)

C07K16/28(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2004135101/15, 2003-05-02

(24)

Start date

2003-05-02

(22)

Actual filing date

2003-05-02

(45)

Published

2011-06-27

(72)

Inventor

Kunz ArturMoran Dzhastin KejtRubino Dzhozef TomasDzhejn NeeraVidunas Judzhin DzhozefSimpson Dzhon MaklinRobbins Pol DehvidMerchant NishitDajdzhosef Dzhon FransisRappen Mark EhdvardDamle Nitin KrishnadzhiPopluehll Ehndrju Dzhordzh

(73)

Holder

Uajt Kholdingz Korporejshn

CONJUGATES "CALIHEAMICIN DERIVATIVE-CARRIER" Russian patent published in 2011 - IPC A61K39/395 C12N15/63 C07K16/28 A61P35/00

Abstract RU 2422157 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of biotechnology and deals with conjugates "caliheamicin derivative-carrier". Essence of invention includes methods of obtaining conjugates "monomer cytotoxic medication-caliheamicin/carrier" with considerably higher loading with medication than in earlier described methods, with low aggregation degree and with low content of low-conjugated fraction (LCF), as well as conjugates "cytotoxic medication-caliheamicin derivative/anti-CD22-antibody". Invention also includes compositions, which contain conjugate with CD22 antibody and application of said conjugates.

EFFECT: invention makes it possible to create conjugates with high loading of cytotoxic medication.

181 cl, 11 ex, 13 tbl, 29 dwg

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RU 2 422 157 C2

Authors

Kunz Artur

Moran Dzhastin Kejt

Rubino Dzhozef Tomas

Dzhejn Neera

Vidunas Judzhin Dzhozef

Simpson Dzhon Maklin

Robbins Pol Dehvid

Merchant Nishit

Dajdzhosef Dzhon Fransis

Rappen Mark Ehdvard

Damle Nitin Krishnadzhi

Popluehll Ehndrju Dzhordzh

Dates

2011-06-27—Published

2003-05-02—Filed