FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of biotechnology and deals with conjugates "caliheamicin derivative-carrier". Essence of invention includes methods of obtaining conjugates "monomer cytotoxic medication-caliheamicin/carrier" with considerably higher loading with medication than in earlier described methods, with low aggregation degree and with low content of low-conjugated fraction (LCF), as well as conjugates "cytotoxic medication-caliheamicin derivative/anti-CD22-antibody". Invention also includes compositions, which contain conjugate with CD22 antibody and application of said conjugates.
EFFECT: invention makes it possible to create conjugates with high loading of cytotoxic medication.
181 cl, 11 ex, 13 tbl, 29 dwg
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Authors
Dates
2011-06-27—Published
2003-05-02—Filed