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(19)

(11)

2 602 878

(13)

(51)

IPC

A61K39/395(2006-01-01)

C12N15/63(2006-01-01)

C07K16/28(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2011108928/15, 2011-03-09

(24)

Start date

2003-05-02

(22)

Actual filing date

2011-03-09

(45)

Published

2016-11-20

(72)

Inventor

Kunz ArturMoran Dzhastin KejtRubino Dzhozef TomasDzhejn NeeraVidunas Judzhin DzhozefSimpson Dzhon MaklinRobbins Pol DevidMerchant NishitDajdzhosef Dzhon FransisRappen Mark EdvardDamle Nitin KrishnadzhiPopluell Endrju Dzhordzh

(73)

Holder

Uajt Kholdingz Korporejshn

CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES Russian patent published in 2016 - IPC A61K39/395 C12N15/63 C07K16/28 A61P35/00

Abstract RU 2602878 C2

FIELD: medicine.

SUBSTANCE: group of inventions relates to a monomeric calicheamicin derivative/antibody conjugate, as well as a method for treating an individual with a proliferative disorder other than cell expression of CD22 antigen on surface thereof, comprising administering a therapeutic dose of said conjugate.

EFFECT: claimed conjugate is characterised by significantly higher drug load than previously described methods with a low degree of aggregation and low conjugate fraction (LCF).

32 cl, 29 dwg, 13 tbl, 9 ex

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RU 2 602 878 C2

Authors

Kunz Artur

Moran Dzhastin Kejt

Rubino Dzhozef Tomas

Dzhejn Neera

Vidunas Judzhin Dzhozef

Simpson Dzhon Maklin

Robbins Pol Devid

Merchant Nishit

Dajdzhosef Dzhon Fransis

Rappen Mark Edvard

Damle Nitin Krishnadzhi

Popluell Endrju Dzhordzh

Dates

2016-11-20—Published

2011-03-09—Filed