FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry, in particular to an antibody-drug conjugate for drug delivery to PTK7-expressing cells, use thereof in preparing a drug for treating a disorder associated with PTK7 expression, as well as a method for production thereof. Also disclosed is a composition for drug delivery into PTK7-expressing cells containing an effective amount of said conjugate. Invention also relates to a method of treating a disorder associated with PTK7 expression involving administering to said subject an antibody-drug conjugate.
EFFECT: invention enables effective drug delivery to PTK7-expressing cells.
26 cl, 23 dwg, 38 tbl, 16 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SITE-SPECIFIC HER2 ANTIBODY-DRUG CONJUGATES | 2016 |
|
RU2745565C2 |
| ANTIBODIES AND ANTIBODY FRAGMENTS FOR SITE-SPECIFIC CONJUGATION | 2016 |
|
RU2757815C2 |
| ANTIBODIES AGAINST EDB AND ANTIBODY-DRUG CONJUGATES | 2017 |
|
RU2758632C2 |
| ANTI-c-MET DRUG CONJUGATE AND USE THEREOF | 2021 |
|
RU2822497C1 |
| NOVEL ANTIBODY CONJUGATES AND USES THEREOF | 2014 |
|
RU2684468C2 |
| HUMANISED ANTIBODIES TO LIV-1 AND USE THEREOF FOR TREATING CANCER | 2011 |
|
RU2608646C2 |
| ANTI-MESOTHELIN ANTIBODY AND CONJUGATE THEREOF WITH MEDICINAL PRODUCTS | 2019 |
|
RU2747995C1 |
| ANTI-CLAUDIN 18.2 ANTIBODY AND ITS ANTIBODY-DRUG CONJUGATE | 2022 |
|
RU2814164C2 |
| METHOD FOR DOUBLE CONJUGATION FOR OBTAINING ANTIBODY-DRUG CONJUGATES | 2018 |
|
RU2771310C2 |
| ANTI-5T4 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES | 2016 |
|
RU2736720C2 |
