RECOVERED PEPTIDE EXHIBITING SPECIFIC ANTI-GDF-8 ANTIBODY BINDING ACTIVITY, RECOVERED NUCLEIC ACID MOLECULE, EXPRESSION VECTOR, HOST CELL, METHOD FOR PRODUCING PEPTIDE, VACCINE COMPOSITION AND METHOD OF ELICITING ANTI-GDF-8 IMMUNE RESPONSE, METHOD OF ANTI-GDF-8 ANTIBODY SELECTION SCREENING AND METHOD OF GDF-8 ACTIVITY DOWN-REGULATION IN ANIMAL Russian patent published in 2011 - IPC C07K14/495 C12N15/18 C07K16/22 C12N15/62 G01N33/53 A61K38/18 A61P37/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to biotechnology, more specifically to producing a neutralising epitopes for an anti-GdF-8 antibody, and can be used in medicine. Produced are peptide versions of the area of 327 to 346 amino acid of the sequence SEQ ID NO: 1 which is specifically bound with rat's monoclonal antibody 788. Peptides are produced by a recombinant method with using a host cell transformed by an expression vector with nucleic acid coding said peptide version. The produced peptides are used to prepare vaccine compositions which are used to elicit an anti-GdF-8 immune response and to enable GDF-8 activity down-regulation in an animal. Also, the produced peptides can be used in a method of anti- antibodies selection screening.

EFFECT: produced peptides exhibit the anti-GdF-8 antibody binding activity thereby applicable for the decreased activity of a growth and differentiation factor 8.

17 cl, 2 dwg, 6 tbl, 5 ex