FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology and medicine. Disclosed is method of increasing levels of erythrocytes or treating anaemia patient. Method involves administering activator of erythropoietin and polypeptide containing part of ActRIIB and part of Fc-immunoglobulin domain, wherein polypeptide is bound with GDF11 and/or myostatin. Invention can be used in medicine.
EFFECT: combined introduction of erythropoietin activator and above described polypeptide enables achieving synergetic effect and increase hematocrit almost by 25 %.
42 cl, 22 dwg, 19 ex
| Title |
Year |
Author |
Number |
| COMBINED ADMINISTRATION OF GDF TRAPS AND ERYTHROPOETIN RECEPTOR ACTIVATORS FOR INCREASING CONTENT OF ERYTHROCYTES |
2010 |
- Sikhra Dzhasbir
- Pirsall Robert Skott
- Kumar Ravindra
|
RU2642302C1 |
| COMBINED USE OF GDF TRAPS AND ACTIVATORS OF ERYTHROPOIETIN RECEPTORS TO INCREASE ERYTHROCYTE CONTENT |
2017 |
- Seehra, Jasbir
- Pearsall, Robert, Scott
- Kumar, Ravindra
|
RU2732229C2 |
| COMBINED USE OF GDF TRAPS AND ERYTHROPOIETIN RECEPTOR ACTIVATORS TO INCREASE ERYTHROCYTE COUNT |
2020 |
- Seehra, Jasbir
- Pearsall, Robert, Scott
- Kumar, Ravindra
|
RU2814047C2 |
| COMPOSITIONS AND METHODS OF PULMONARY HYPERTENSION TREATMENT |
2017 |
- Kumar, Ravindra
- Knopf, John
|
RU2748278C2 |
| ACTIVIN-ACTRII ANTAGONISTS AND USES THEREOF FOR TREATING BONE AND OTHER DISORDERS |
2013 |
- Sloan Viktor Shorr
- Khruska Kejt
- Fan Ifu
- Sung Viktoriya
- Stivens Rendall
- Smit Uillyam
|
RU2678117C2 |
| NOVEL HYBRID ACTRIIB LIGAND TRAP PROTEINS FOR TREATING DISEASES ASSOCIATED WITH MUSCULAR ATROPHY |
2016 |
|
RU2733492C2 |
| ACTIVIN-ActRIIa-Fc ANTAGONISTS AND USE THEREOF FOR TREATING OR PREVENTING BREAST CANCER |
2008 |
- Nopf Dzhon
- Sikhra Dzhasbir
- Kumar Ravindra
|
RU2473362C2 |
| GBO-ACTRIIB RECOMBINANT PROTEIN FOR INCREASING MUSCLE MASS IN FARM ANIMALS AND POULTRY |
2022 |
- Lyashchuk Aleksandr Mikhajlovich
- Lunin Vladimir Glebovich
- Lunin Afanasij Vladimirovich
|
RU2792817C1 |
| NUETRALISING ANTIBODIES AGAINST GDF-8 AND THEIR APPLICATION |
2003 |
- Fel'Dman Gejtruida M.
- Dehvis Monik V.
- Song Kening
- Vol'Fman Nehjl M.
- Grouv-Bridzhes Kristi
- Fild Ehnn
- Rassell Kehrolajn
- Val'Ge-Arkher Fija
|
RU2360925C2 |
| FUSED IMMUNOGLOBULIN PROTEINS |
2008 |
- Sung,Joung Chul
- Jang,Sekhvan
|
RU2530168C2 |
