METHOD OF MICRONISATION OF N-CARBAMOYL-METHYL-4-PHENYL-2-PYRROLIDONE AND MEDICATION, CONTAINING WATER-DISPERSED ORGANIC MEDICINAL SUBSTANCE IN FORM OF MICRONISED POWDER OF N-CARBAMOYL-METHYL-4-PHENYL-2-PYRROLODONE Russian patent published in 2011 - IPC A61K9/14 A61K31/40 A61J3/02 A61P25/28

Abstract RU 2423969 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical industry, and deals with method of obtaining highly dispersed powders of organic medicinal substances and can be used in manufacturing novel medications. Method of micronosation of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone is realised by the following method. Evapouration of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone is realised in neutral gaseous medium with vacuum 950-10 Pa, and precipitation of its vapours is carried out at rate 10¹⁵ - 10¹⁷ molec/sec·cm² on precipitation surface, which has temperature 120 - 30°C, precipitation surface being inclined at angle 15-80° relative to direction of precipitation rate vector, rate of evapouration of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone exceeds rate of their precipitation in 1.2-2.5 times. Also claimed is medication, containing water-dispersive organic medicinal substance in form of micronised powder of N-carbamoyl-methyl-4-phenyl-2-pyrrolidone.

EFFECT: elaboration of efficient method of obtaining highly dispersive powders of organic medicinal substances.

2 cl, 2 ex, 2 dwg

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RU 2 423 969 C2

Authors

Komarov Valerij Sergeevich

Dates

2011-07-20—Published

2007-10-12—Filed