FIELD: medicine, pharmaceutics.
SUBSTANCE: method lies in the following: initial organic medicinal substance and auxiliary volatile substance are simultaneously evaporated in gaseous medium, which has vacuum 102 - 10-1 Pa. Obtained vapours of medicinal substance and auxiliary volatile substance are co-condensed respectively with rates 1014-5·1017molec/sec·cm2 and 3·1014 - 1018 molec/sec·cm2 respectively on precipitation surface with temperature from -196 to -50°C. Surface of precipitation is inclined at angle 10-90° relative to bisector of angle, formed by vectors of components precipitation and constituting 5-170°. When processes of co-condensation are over, temperature of precipitation surface is brought to temperature of surrounding medium with simultaneous removal from co-condensate of auxiliary volatile substance by pump-down in vacuum, process of pumping down auxiliary volatile substance is performed with heating precipitation surface to temperature which does not exceed 70°C, with further bringing temperature of precipitation surface to temperature of surrounding medium.
EFFECT: invention ensures one-stage method of obtaining micronised powders of organic medicinal substances with increased rate of solubility and bioavailability.
2 cl, 4 dwg, 5 ex
