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2 424 230

(13)

(51)

IPC

C07D207/16(2006-01-01)

C07D211/60(2006-01-01)

C07D265/30(2006-01-01)

C07D277/06(2006-01-01)

A61K31/40(2006-01-01)

A61K31/426(2006-01-01)

A61K31/445(2006-01-01)

A61K31/5375(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2008128569/04, 2006-12-15

(24)

Start date

2006-12-15

(22)

Actual filing date

2006-12-15

(45)

Published

2011-07-20

(72)

Inventor

Kastro Al'Fredo S.Grogan Majkl Dzh.Kholson Ehduard B.Khopkins Brajan T.Kouni Naj O.Peljuzo StefanSnajder Daniel A.

(73)

Holder

Infiniti Diskaveri, Ink.

COMPOUNDS AND METHODS OF INHIBITING INTERACTION OF BCL PROTEINS WITH BINDING COMPONENTS Russian patent published in 2011 - IPC C07D207/16 C07D211/60 C07D265/30 C07D277/06 A61K31/40 A61K31/426 A61K31/445 A61K31/5375 A61P35/00

Abstract RU 2424230 C2

FIELD: chemistry.

SUBSTANCE: invention relates to heterocyclic compounds of formula I

, where Y denotes -(C=O)-, X denotes -N(R₁₀)-, A denotes -C(A₁)(A₂)-, B denotes O, S, -(C=O)- or is characterised by formula

, where D denotes N or CR₁₀, and where the remaining substitutes are described in the claim. Compounds of formula I, as well as composition based on said compounds can inhibit the bcl-2 family proteins.

EFFECT: possibility of using said compounds and compositions in treating or modulating disorders associated with hyper-proliferation, such as cancer.

20 cl, 17 ex

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RU 2 424 230 C2

Authors

Kastro Al'Fredo S.

Grogan Majkl Dzh.

Kholson Ehduard B.

Khopkins Brajan T.

Kouni Naj O.

Peljuzo Stefan

Snajder Daniel A.

Dates

2011-07-20—Published

2006-12-15—Filed