COMPOUNDS AND METHODS OF INHIBITING INTERACTION OF BCL PROTEINS WITH BINDING COMPONENTS Russian patent published in 2011 - IPC C07D261/02 C07D413/10 C07D413/12 C07D413/14 A61K31/42 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula 1, compounds of formula 5 and pharmaceutically acceptable salts thereof. In formulae 1 5 Y denotes -C(O)-, X denotes -N(R₁₁)-, R₁ denotes a residue of formula 1a or 1b - for formula 1 or residue of formulae 5a or 5b - for formula 5 1a 1b 5a 5b, R₂ and R₇ independently denote H, hydroxyl or (C₁-C₆)alkyl; R₃ and R₆ each independently denotes H, hydroxyl or (C₁-C₆)alkyl; R₄ and R₅ each independently denotes H or (C₁-C₆)alkyl; the rest of the radicals are described in the formula of invention. The invention also relates to separate compounds given in the formula of invention, a pharmaceutical composition having Bcl bound protein inhibiting properties, which contains a therapeutically effective amount of the disclosed compound, a method of treating a bc1 mediated disorder, involving introduction of a therapeutically effective amount of the disclosed compound and a method of treating a bc1 mediated disorder involving administration to a patient in need of treatment of an effective amount of camptothecin and therapeutically effective amount of the disclosed compound.

EFFECT: high efficiency of the composition.

84 cl, 12 tbl, 1 dwg, 217 ex