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2 424 803

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IPC

A61K31/46(2006-01-01)

A61K47/00(2006-01-01)

A61K9/20(2006-01-01)

A61P25/06(2006-01-01)

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Application

2008113043/15, 2008-04-07

(24)

Start date

2008-04-07

(22)

Actual filing date

2008-04-07

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Published

2011-07-27

(72)

Inventor

Seredenin Sergej BorisovichPjatin Boris MikhajlovichAvdjunina Nina IvanovnaAlekseev Konstantin ViktorovichGrushevskaja Ljubov' NikolaevnaVolkova Marina Jur'EvnaUstinova Marija IsaakovnaBlynskaja Evgenija ViktorovnaMirzojan Ruben SimonovichGan'Shina Tamara SergeevnaKostochka Leonid MikhajlovichZherdev Vladimir Pavlovich

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Meditsinskikh Nauk Nauchno-Issledovatel'Skij Institut Farmakologii Imeni V.V. Zakusova Ramn Farmakologii Imeni V.V.Zakusova Ramn)

PHARMACEUTICAL COMPOSITION WITH ANTIMIGRAINE ACTION (VERSIONS) Russian patent published in 2011 - IPC A61K31/46 A61K47/00 A61K9/20 A61P25/06

Abstract RU 2424803 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of medicine, in particular, to pharmaceutics, and deals with pharmaceutical composition, which contains as acting substance therapeutically efficient amount of hydrochloride of 3-(3,4,5-tromethoxybenzoyloxyimino)-8-methyl-8-azabicylo [3,2,1] octane (tropoxin), and as auxiliary substances, at least, one, selected from the group, which includes starch, lactose, microcrystalline cellulose (MCC), ludipress, sodium phosphate twice-substituted, polyvinylpyrrolidone, methylcellulose, carboxymethylcellulose and its sodium salt, oxypropylcellulose, oxypropylmethylcellulose, mannite, sorbite, and, if necessary, stearic acid and/or its salt and/or aerosil Novel composition is represented in two specific versions. Composition is made in form of solid dosed medication, preferably, in form of tablet. Solid dosed drug forms in accordance with invention satisfy all demands of State Pharmacopoeia currently in force.

EFFECT: compositions by invention easily release acting substance, which ensures its high bioavailability.

10 cl, 4 tbl, 7 ex

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RU 2 424 803 C2

Authors

Seredenin Sergej Borisovich

Pjatin Boris Mikhajlovich

Avdjunina Nina Ivanovna

Alekseev Konstantin Viktorovich

Grushevskaja Ljubov' Nikolaevna

Volkova Marina Jur'Evna

Ustinova Marija Isaakovna

Blynskaja Evgenija Viktorovna

Mirzojan Ruben Simonovich

Gan'Shina Tamara Sergeevna

Kostochka Leonid Mikhajlovich

Zherdev Vladimir Pavlovich

Dates

2011-07-27—Published

2008-04-07—Filed