FIELD: chemistry.
SUBSTANCE: invention describes methods of purifying lercanidipine hydrochloride, which employ binary systems of an alcohol-containing solvent such as methanol or an aliphatic ester-containing solvent such as isopropylacetate. Described also is lercanidipine hydrochloride in polymorphous form V, synthesis methods thereof, as well as a pharmaceutical composition for treating hypertension containing lercanidipine hydrochloride in polymorphous form V.
EFFECT: high efficiency owing to use of cheap reagents, low amount of wastes, as well as obtaining clean lercanidipine hydrochloride.
20 cl, 4 ex, 1 tbl, 3 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| FORM IV OF IVABRADINE HYDROCHLORIDE | 2012 |
|
RU2619121C2 |
| SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SAME | 2014 |
|
RU2663663C2 |
| METHOD FOR PREPARING SERTRALINE HYDROCHLORIDE POLYMORPHOUS FORMULATION | 2003 |
|
RU2310647C2 |
| CRYSTALLINE SOLVATES OF HYDROCHLORIDE 6-(PIPERIDIN-4-YLOXY)-2H-ISOQUINOLIN-1-ONE | 2012 |
|
RU2619129C2 |
| METHOD FOR PRODUCING 2-[(3R)-3-METHYLMORPHOLIN-4-YL]-4-(1-METHYL-1H-PYRAZOL-5-YL)-8-(1H-PYRAZOL-5-YL)-1,7-NAFTHYRIDINE | 2019 |
|
RU2802512C2 |
| CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL][3-HYDROXY-3-(PIPERIDINE-2-YL)AZETIDINE-1-YL]METHANONE | 2016 |
|
RU2762181C2 |
| CRYSTALLINE FORM OF COMPOUND OF PYRIMIDO [6, 1-a] ISOQUINOLIN-4-ONE | 2011 |
|
RU2577541C2 |
| CRYSTALLINE ANHYDROUS FORM OF CABAZITAXEL, PROCESS FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | 2014 |
|
RU2672110C2 |
| NOVEL SALTS OF DERIVATIVES POSSESSING ANTICONVULSANT EFFECT | 2002 |
|
RU2320665C2 |
| SOLID FORMS | 2007 |
|
RU2496780C2 |
