FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to a method of producing biphosphonic acids and their pharmaceutically acceptable salts applied in medicine. In the offered method, the compounds of general formula I 
or their pharmaceutically acceptable salts where R1 represents alkyl, arylalkyl, an aromatic or heteroaromatic group, are produced by a reaction of carboxylic acid of formula II 
or its salts, formula II in which R1 has said values, with phosphorous acid and phosphorous trichloride in an aprotonic polar solvent selected from N,N'-dimethylethylene urea (DMEU), N,N'-dimethylpropylene urea (DMPU), 1-methyl-2-pyrrolidone (NMP) or their mixtures.
EFFECT: new method of producing biologically active compounds is implemented.
14 cl, 4 ex
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