METHOD FOR SYNTHESIS OF AMINOALKYLENE PHOSPHONIC ACID Russian patent published in 2019 - IPC C07F9/38 C07F9/572 C07F9/6506 C07F9/653 A01N57/20 

FIELD: chemistry.

SUBSTANCE: present invention relates to a method of synthesis of aminoalkylene phosphonic acid or its phosphonate esters and can be used in chemical industry. Proposed method comprises the steps of: a) forming, in the presence of aldehyde and acid catalyst, a reaction mixture by mixing compound (a.1.) containing at least one HNR¹R² fragment, or a salt thereof with a compound (a.2.) containing one or more anhydride P-O-P fragments, wherein fragments contain one atom P in degree of oxidation (+III) and one atom P in degree of oxidation (+III) or (+V), where ratio of moles of aldehyde to N-H fragments is 1 or more, and where ratio of fragments of N-H to anhydride fragments P-O-P is 0.3 or more, and where the aldehyde has the general formula R-CO-H, where R is selected from a group consisting of hydrogen, an aliphatic moiety, an araliphatic fragment, an aromatic moiety and a heterocyclic moiety, where total number of carbon atoms and heteroatoms ranges from 1 to 11, compound (a.1.) is characterized by that (a.1.1) R¹ and R² are independently selected from hydrogen, C₁-C₆alkyl, C₁-C₆alkenyl, C₁-C₆alkynyl, C₁-C₆acyl, optionally containing ethylenically unsaturated double bond, and (meth)acryloyl C₁-C₆-fragment, wherein C₁-C₆-part of said fragments has a normal, branched or cyclized chain and optionally substituted with one or more fragments selected from C₁-C₄hydrocarbon, aryl and aralkyl, and optionally contains one or more heteroatoms selected from oxygen, nitrogen and sulfur, and optionally contains one or more carbonyl moieties, or (a.1.2) R¹ and R² form a circular structure, where N-H is included in said ring, and where said ring is optionally substituted with one or more fragments selected from C₁-C₄hydrocarbon, aryl and aralkyl, and optionally contains one or more heteroatoms selected from oxygen, nitrogen and sulfur, and optionally contains one or more carbonyl fragments, and where compounds (a.2.) containing anhydride P-O-P fragments which contain one P atom in oxidation state (+III) and another P atom in oxidation state (+III) or (+V) are selected from tetra phosphorus hexaoxide, P₄O₇, P₄O₈, P₄O₉, tetraethyl pyrophosphite and combinations thereof, b) adding water to the reaction mixture; and c) recovering the resulting compound containing a fragment of aminoalkylene phosphonic acid or one of its phosphonate esters.

EFFECT: novel efficient method of producing aminoalkylene phosphonic acid and phosphonate esters thereof.

19 cl, 21 ex, 2 tbl