METHODS FOR SYNTHESIS OF 3-(4-(2,4-DIFLUOROBENZYLOXY)-3-BROMO-6-METHYL-2-OXOPYRIDIN-1 (2H)-YL)-N-4-DIMETHYLBENZAMIDE Russian patent published in 2011 - IPC C07D213/64 A61K31/4412 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a method for synthesis of (-)-3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide or a pharmaceutically acceptable salt thereof, involving the following steps: a) bringing compounds of formula V into contact with a brominating agent in the presence of at least one solvent to obtain a compound of formula IV, b) bringing the formula IV compound into contact with hydrolase in the presence of a buffer solution to obtain a compound of formula X, c) bringing the formula X compound into contact with an activating reagent in the presence of at least one solvent and then bringing the obtained mixture into contact with methylamine to obtain a compound of formula IX, d) bringing the formula IX compound into contact with 2,4-diflluorobenzylhalide in the presence of a base and at least one solvent; where the compounds V, IV, IV, X and IX are as described in the claim. The invention also relates to novel compounds, specifically to methyl-3-(3-bromo-4-hydroxy-6-methyl-2-oxopyridin-1(2H)-yl)-4-methylbenzoate, (-)-3-(3-bromo-4-hydroxy-6-methyl-2-oxopyridin-1(2H)-yl)-4-methylbenzoic acid and (-)-3-(3 -bromo-4-hydroxy-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide.

EFFECT: described is a novel method for synthesis of (-)-3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide, which avoids several time-consuming operations, for example multiple extractions, and also avoids use of expensive materials.

12 cl, 2 ex