METHOD OF NONINVASIVE QUALITATIVE AND QUANTITATIVE ANALYSIS OF MAGNETOCONTROLLABLE NANOMEDICINES AND REAL-TIME FUNCTION EVALUATION IN EXPERIMENTAL ANIMALS Russian patent published in 2011 - IPC A61K49/06 B82Y5/00 A61B5/55 

Abstract RU 2427390 C2

FIELD: medicine.

SUBSTANCE: invention refers to experimental medicine, namely to oncology, and can be used for qualitative and quantitative analysis of nonlinearly magnetised magnetocontrollable nanomedicines (MN) introduced in bodies of experimental animals, and real-time MN function evaluation. That is ensured by variation of MN responses to variable magnetic fields within electron-sensor scanning of an animal's body by an apparatus generating and emitting variable magnetic fields, receiving and recording MN responses found in a tumour and a liver. The response value indicates the presence and concentration of MN in experimental animals. The MN functions is shown by the relation of the tumour MN content to the liver MN content. If observing MNtumour> MNliver, MN can have therapeutic functions. MNtumour ≤MNliver shows MN exercising diagnostic functions.

EFFECT: method of analysis is noninvasive, informative and safe, and allows quantitative and qualitative analysis of MN distribution in the animal's body, and evaluation of the efficacy of route-specific MN concentration and immobilisation in a tumour.

3 tbl, 6 ex, 10 dwg

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RU 2 427 390 C2

Authors

Brusentsov Nikolaj Antonovich

Nikitin Petr Ivanovich

Pirogov Jurij Andreevich

Brusentsova Tat'Jana Nikolaevna

Nikitin Maksim Petrovich

Jur'Ev Mikhail Vasil'Evich

Kuprijanov Dmitrij Alekseevich

Dubina Andrej Ivanovich

Uchevatkin Andrej Alekseevich

Ivanov Andrej Valentinovich

Dates

2011-08-27Published

2009-06-08Filed