PYRIDINE- OR PYRIMIDINE-2-CARBOXAMIDE DERIVATIVES Russian patent published in 2011 - IPC C07D417/12 C07D417/14 C07D401/12 C07D213/81 C07D403/12 C07D401/14 A61K31/4427 A61K31/506 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. In formula (I) Y is C-R⁴ and Z is CH; or Y is C-R⁴ and Z is N; or Y is N and Z is CH; R¹ is a 5- or 6-member ring of formula (II) or (III): R² is H, C₁-C₇-alkyl; R³ is phenyl, pyrazolyl, isoxazolyl, pyridinyl, pyrimidinyl or pyrazinyl, which can possibly be substituted with one, two or three substitutes selected from a group consisting of: CN, CI, F, Br, CF₃, CHF₂, C₁-C₇-alkyl, -O-C₁-C₇-alkyl, -(CH₂)_m-R^c, -O-CH₂F, -O-CHF₂, -O-CF₃, -S(O)₂-R^d; R⁴ is H, C₁-C₇-alkyl; R⁵ is H, CI, F, Br, CN, CF₃, CHF₂, C₁-C₇-alkyl, -C₃-C₆-cycloalkyl, -(CH₂)_m-R^e or -(CO)-NRⁱR^j; R⁶ is C₁-C₇-alkyl; R⁷ is H, CI, F, CN or C₁-C₇-alkyl; R^c is -OH; R^d is C₁-C₇-alkyl; R^e is -CH₂F, -CHF₂, -CF₃, CN, C₁-C₇-alkoxy; Rⁱ, R^j independently denote H or C₁-C₇-alkyl; m equals 1-4. The invention also relates to a medicinal agent having mGluR5a receptor antagonist properties, containing one or more of the disclosed compounds as an active component.

EFFECT: high efficiency of the medicinal agent.

24 cl, 208 ex