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2 452 738

(13)

(51)

IPC

C07D471/04(2006-01-01)

C07D239/02(2006-01-01)

A61K31/506(2006-01-01)

A61K31/454(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2009117475/04, 2007-11-20

(24)

Start date

2007-11-20

(22)

Actual filing date

2007-11-20

(45)

Published

2012-06-10

(72)

Inventor

Zhang ChaoZhang DzhiazhongIbrakhim Prabkha N.Artis Din R.Bremer RajanVu GuoksianZhu Khong'JaoNespi Marika

(73)

Holder

Plekssikon, Ink.

COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USE THEREOF Russian patent published in 2012 - IPC C07D471/04 C07D239/02 A61K31/506 A61K31/454 A61P35/00

Abstract RU 2452738 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound having chemical structure of formula II , all salts and stereoisomers thereof, where the value of radicals D, A₂ and B are as described in paragraph 1 of the claim. The invention also relates to a composition having activity as a c-kit and c-fms modulator, a method of treating a subject suffering from a disease or condition mediated by c-kit and c-fms and a kit for modulating c-kit and c-fms.

EFFECT: novel compounds which can be useful in treating c-kit-mediated diseases or conditions and/or c-fms-mediated diseases or conditions are obtained and described.

21 cl, 44 ex

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RU 2 452 738 C2

Authors

Zhang Chao

Zhang Dzhiazhong

Ibrakhim Prabkha N.

Artis Din R.

Bremer Rajan

Vu Guoksian

Zhu Khong'Jao

Nespi Marika

Dates

2012-06-10—Published

2007-11-20—Filed