FIELD: medicine.
SUBSTANCE: invention describes adhesive product consisting of stretchable base and adhesive layer that is put in thin layer on at least one side of the base, where the stretchable base contains connective layer of fabric subject to goffering process, the adhesive layer contains 10% by weight or more of methyl salicylate from total mass of the layer, moisture permeability of all adhesive product is 1-350 g/m2*24 hours measured at the temperature 40°C and relative humidity 90%, and methyl salicylate has AUC0-24 in plasma in the range from 3.0 to 60.0 ng*h/ml in the values of average ± standard deviation, salicylic acid as the metabolite of methyl salicylate has AUC0-24 in plasma in the range from 5,000 to 13,000 ng*h/ml in the values of average ± standard deviation, when the adhesive product is put on the human skin for 8 hours so that the contacting amount of adhesive layer is 50-300 g/m2 and the area of contact is 280 cm2.
EFFECT: product is capable of stable absorption through the skin.
7 cl, 3 tbl, 3 dwg, 6 ex
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Authors
Dates
2012-02-10—Published
2007-08-01—Filed