METHOD OF PRODUCING LIPOSOMAL FORM OF ISONIASIDE Russian patent published in 2011 - IPC A61K31/4409 A61K9/127 A61P31/06 

FIELD: medicine.

SUBSTANCE: method of producing small-size (no more than 400 nm) liposomes containing INH included in liposomes in the maximally high concentration differs by the fact that there is prepared an isoniaside solution of the concentration 10-95 mg/ml in an aqueous medium; a surface of the prepared solution is coated with a layered powder of mixed lipids consisting of glycosphingolipids and phospholipids, and the powder is dispersed in weak mixing; then the dispersion is incubated at temperature 55-80°C for 10-20 minutes; the prepared liposomes are separated from INH by a gel filtration method.

EFFECT: method improvement.

7 cl, 2 dwg, 1 tbl, 4 ex