METHOD OF OBTAINING CAPSULATED FORM OF ANTITUBERCULOSIS MEDICATIONS OF RIFAMPICIN SERIES Russian patent published in 2011 - IPC A61K31/496 A61K9/10 A61P31/06 B82B3/00 B82Y40/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of pharmaceutics, namely to method of obtaining capsulated form of antibiotics of rifampicin series for treating tuberculosis. Claimed is method of obtaining liposomal form of antituberculosis medications of rifampicin series rifampicin (RM) or rifabutin (RB) which differs by the fact that antibiotic is dissolved in isotonic solution with medium pH value 2-3, after which on the surface of said solution applied in layers is powder of lipid mixture, which contains 50-70% of glycosphyngolipids, 30-50% phospholipids and 3% of cholesterol and triacetylglicerides with further dispersion with slight mixing at room temperature, pH of dispersion is brought to neutral value by base addition, dispersion is heated for 10-40 min at temperature 60-70°C with further evaluation of degree of antibiotic inclusion by method of spectrophotometry after carrying out gel-filtration.

EFFECT: method ensures obtaining medication antibiotic of rifampicin series with high bioaccessibility.

5 cl, 1 ex, 1 tbl, 2 dwg