LIPOSOMAL SUSPENSIONS STABILISER Russian patent published in 2018 - IPC A61K9/127 C08B37/08 A61K31/722 

FIELD: pharmacology.

SUBSTANCE: conjugate of the invention is a compound of formula (C₆O₄H₉NH₂)_m(C₆O₄H₉NHX)_n, wherein the remainder of the polyethylene glycol derivative, which is a monomethoxy-PEG succinate acts as a substituent on the amino group X, the molecular weight of chitosan used to prepare the conjugate is 15 to 120,000 daltons, am and n are the number of units in the molecule, where m/n is 6 to 19. The proposed method involves preparation of a solution of N-hydroxysuccinimide ester of PEG-hemisuccinate in dimethylformamide or dimethylsulfoxide, mixing of the solution prepared with an acidic solution of chitosan with a molecular weight of 15-120 kDa, and adjustment of the resulting mixture to a pH of 7.5-8.0, followed by purification by dialysis against buffer solution.

EFFECT: new substance effective for liposomal suspensions stabilization is disclosed, and an effective method for its preparation.

3 cl, 3 dwg, 4 ex