ORALLY BIOAVAILABLE PRODRUGS OF (+)-3-HYDROXYMORPHINAN FOR PREVENTING OR TREATING PARKINSON'S DISEASE Russian patent published in 2011 - IPC C07D221/28 A61K31/485 A61P25/16 

Abstract RU 2430089 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof:

,

where A is a single bond or oxygen; R1 is selected from a group comprising hydrogen; -C(O)OC1-10alkyl and -C(O)OC1-10alkyl-phenyl; and R2 is selected from a group comprising C1-10alkyl, (CH2)n-phenyl, adamantinyl, adamantinyl, C1-10alkyl substituted with C3-10carbocycle, and C3-10carbocycle, where n assumes values from 0 to 4.

EFFECT: novel compounds and salts thereof which can be used in preventing or treating Parkinson's disease are obtained and described.

6 cl, 105 ex, 3 tbl, 2 dwg

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RU 2 430 089 C2

Authors

Li Dzinkhva

Kim Dzeongmin

Dzung Miung Ehun

Kim Dzong Jup

Song Kvang-Seop

Son Ehun Dzung

Li Suk Kho

Khan Kho Kiun

Kim Min Dzu

Li Minvoo

Dates

2011-09-27Published

2008-03-07Filed