SUBSTITUTED OXADIAZOLE DERIVATIVES AND USE THEREOF AS OPIOID RECEPTOR LIGANDS Russian patent published in 2011 - IPC C07D271/06 C07D413/04 C07D413/06 C07D413/08 A61K31/4245 A61P25/04 

FIELD: chemistry.

SUBSTANCE: invention relates to substituted oxadiazole derivatives of general formula , where X denotes CH, CH₂, CH=CH, CH₂CH₂, CH₂CH=CH or CH₂CH₂CH₂, R¹ denotes an unsubstituted or mono- or disubstituted phenyl or pyrrolyl residue or an unsubstituted or mono- or disubstituted phenyl connected through a C₁-C₃alkyl or a thienyl or indolyl residue, where the said substitutes are selected from a group comprising F, Cl, Br, OCF₃, O-C₁-C₆alkyl or C₁-C₆alkyl, R² denotes an unsubstituted or mono- or disubstituted phenyl or thienyl residue or an unsubstituted or mono- or disubstituted phenyl residue connected through a C₁-C₃alkyl, where the said substitutes are selected from a group comprising F, Cl, and R³ and R⁴ denote a saturated straight C₁-C₆alkyl in form of a racemate, diastereomers, mixture of enantiomers and/or diastereomers, or a specific diastereomer, bases and/or salts with physiologically compatible acids. The invention also relates to a method of producing said compounds and a medicinal agent based on said compounds and having affinity to the µ-opioid receptor.

EFFECT: obtaining novel compounds and a medicinal agent based on said compounds, which can be used in medicine to pain killing and for treating depression, enuresis, diarrhoea, skin itching, alcohol and drug abuse, drug induced addiction, aspontaneity or for anxiolyis.

11 cl, 2 tbl, 331 ex