BIPHENYLSULFONYLCYANAMIDES, METHOD FOR THEIR PREPARING AND THEIR APPLYING AS DRUGS Russian patent published in 2005 - IPC

FIELD: organic chemistry, pharmacy.

SUBSTANCE: invention relates to new biphenylsulfonylcyanamides of the formula (I): wherein R1 means: 1. (C₁-C₈)-alkyl; 4. -C_nH_2n-nn-Y wherein nn = 0 or 2 and n = 0-4, and n is not 0 or 1 if nn = 2; 5. C_nH_2n-nn-Y wherein nn = 0 or 2 and n = 1-4, and n is not 1 if nn = 2, and 1 hydrogen atom in bivalent residue C_nH_2n-nn is substituted with amino-group or NR(22)R(23); R2 means: 2. (C₁-C)-alkyl; 4. (C₂-C₁₂)-alkenyl; 5. (C₂-C₈)-alkynyl; 6. -C_nH_2n-nn-Z wherein nn = 0 or 2; n = 0-4, and n is not or 1 if nn = 2; 7. -C_nH_2n-nn-Z wherein nn = 0 or 2; n = 1-4, and n is not 1 if nn = 2, and 1 hydrogen atom in bivalent residue C_nH_2n-nn is substituted with a residue taken among a series: 1. phenyl; 3. NR(22)R(23); 5. COOR(16); R3 and R4 mean hydrogen atom; R5, R6 and R7 mean independently of one another hydrogen atom (H), (C₁-C₈)-alkyl; SO₂-(C₁-C₄)-alkyl, F, Cl, Br, J, OR(10) wherein R(10) means hydrogen atom, (C₁-C₄)-alkyl that is substituted if necessary with methoxy- or ethoxy-group; R(9) means OR(13) wherein R(13) means hydrogen atom, H,(C₁-C₈)-alkyl;X means carbonyl group, -CO-CO- or sulfonyl group; Y and Z mean independently of one another: 1. phenyl, 1-naphthyl, 2-naphthyl; 2. one of residues determined in cl. 1 substituted with 1-5 similar or different residues taken among a series: phenyl, F, Cl, Br, J, CF₃, SO_qR(18), OR(16), NR(19)R(20), -CN, NO₂, COR(9), or two residues form methylenedioxy-group; 3. furyl, thienyl, pyridyl, benzimidazolyl, indolyl, benzothiophenyl, dihydroquinazolinyl; 5. (C₃-C₁₀)-cycloalkyl wherein cyclopropyl, cyclopentyl, cyclohexyl and indalyl are preferable; 6. one of residues determined in cl. 5 substituted with phenyl; R(16) means: 1. hydrogen atom; 2. (C₁-C₄)-alkyl; 3. (C₁-C₄)-alkyl substituted with (C₁-C₄)-alkoxy-group; R(19) and R(20) mean independently: hydrogen atom (H), (C₁-C₄)-alkyl; R(22) and R(23) mean independently of one another hydrogen atom (H) or CO-OR(24) wherein R924) means -C_nH_2n-phenyl wherein n = 1-4; q = 2; and their physiologically acceptable salts. Compound of the formula (I) inhibit sodium-dependent chloride-bicarbonate exchange "NCBE".

EFFECT: improved preparing method, valuable medicinal properties of compounds.

4 cl, 2 tbl, 568 ex