FIELD: organic chemistry, medicine, pharmacology.
SUBSTANCE: invention relates to compound of the formula (I): or (II):
wherein R1 and R2 are chosen independently from hydrogen, optionally substituted alkyl or the group: -D-E wherein R represents a covalent bond or alkylene; E represents optionally substituted alkoxy-group, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted alkenyl or optionally substituted alkynyl under condition that if D represents a covalent bond then E can't represents alkoxy-group; R3 represents hydrogen atom, optionally substituted alkyl or optionally substituted cycloalkyl; X represents optionally substituted arylene or heteroarylene; Y represents a covalent bond or alkylene wherein one carbon atom can be substituted optionally for -O-, -S- or -NH-, and optionally substituted hydroxy-, alkoxy-, optionally substituted amino-group or -COR wherein R represents hydroxy-, alkoxy- or amino-group under condition that if an optional substitute represents hydroxy- or amino-group then it can't be adjacent with a heteroatom; Z represents hydrogen atom, optionally substituted monocyclic aryl or optionally substituted monocyclic heteroaryl under condition that Z represents hydrogen atom only under condition that Y represents a covalent bond, and X represents optionally substituted 1,4-pyrazolene, and under condition that if X represents optionally substituted arylene then Z represents optionally substituted monocyclic heteroaryl. Also, invention describes a method for treatment of the morbid state by inhibition of adenosine receptors describes as A2B based on compounds of the formula (I) or the formula (II). Invention provides synthesis of novel compounds possessing useful biological properties.
EFFECT: valuable medicinal properties of compounds.
32 cl, 35 ex
Title | Year | Author | Number |
---|---|---|---|
ANTAGONISTS OF ADENOSINE A RECEPTORS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR THEIR PREPARING | 2002 |
|
RU2318824C2 |
METHOD OF WOUND HEALING WITH APPLYING ANTAGONISTS OF A ADENOSINE RECEPTOR | 2005 |
|
RU2385322C2 |
METHOD OF PREVENTION AND TREATMENT OF LIVER DISEASE WITH APPLICATION OF RECEPTOR A ANTAGONISTS | 2007 |
|
RU2457842C2 |
METHOD OF PREVENTION AND TREATMENT OF RESPIRATORY WAYS REMODELLING AND PNEUMONIA WITH APPLICATION OF ANTAGONISTS OF ADENOSINE RECEPTORS A | 2005 |
|
RU2391103C2 |
METHOD OF PRODUCING ANTAGONISTS OF ADENOSINE RECEPTORS A AND INTERMEDIATE PRODUCTS | 2004 |
|
RU2374247C2 |
PRODRUG OF ADENOSINE A RECEPTOR ANTAGONISTS | 2006 |
|
RU2415858C2 |
GRISEOFULVIN COMPOUND AND ITS PHARMACEUTICAL APPLICATION | 2018 |
|
RU2774618C2 |
HERBICIDE AGENT BASED ON ARYLSULFONYLAMINOCARBONYLTRIAZOLINONES | 1997 |
|
RU2240691C2 |
PYRAZOLOPYRIMIDONE OR PYRROLOTRIAZONE DERIVATIVES, METHOD OF PREPARING SAME AND PHARMACEUTICAL APPLICATIONS THEREOF | 2014 |
|
RU2674977C2 |
CARBOSTYRIL COMPOUND | 2005 |
|
RU2430920C2 |
Authors
Dates
2008-03-10—Published
2003-05-06—Filed