FIELD: chemistry.
SUBSTANCE: invention relates to a compound of formula I 
, isomer thereof of formula IA 
, mixture of isomers thereof IA/C 
, synthesis method thereof, as well as methods of producing compounds of formula IVA 
from compounds of formula IA, involving reduction and removal of protection from compounds of formula IA via hydrogenolysis using H2 and a catalytic amount of Pd/C, in the presence of trifluoroacetic acid to obtain a compound of formula VA; further reaction of this compound with Cbz-t-leu-OH, EDC and HOBt to obtain a compound of formula VIA; reaction of compound VIA with H2 and a catalytic amount of Pd/C in the presence of citric acid to obtain an amine and reaction of said amine and 4-amino-3-chlorobenzoic acid in the presence of CDMT and NMM to obtain a compound of formula IVA.
EFFECT: fewer synthesis steps and high output while using dynamic crystallisation.
13 cl, 5 ex
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