FIELD: chemistry.
SUBSTANCE: invention relates to methods for the synthesis of halichondrin macrolides and their analogues, using a cyclization reaction strategy. The strategy, according to the present invention, includes the impact on an intermediate product of Prince reaction conditions to obtain macrolide. The invention also relates to compounds used as intermediate products in the synthesis of halichondrin macrolides or their analogues and to methods for their production.
EFFECT: obtaining intermediate products used in the synthesis of halichondrin macrolides or their analogues.
29 cl, 8 ex
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