METHOD OF PRODUCING SODIUM SALTS OF 5-NRR-TETRAZOLO[1,5-a]-1,3,5-TRIAZIN-7-ONES Russian patent published in 2011 - IPC C07D487/04 

FIELD: chemistry.

SUBSTANCE: described is a method of producing novel compounds of general formula , where NR₁R₂=NH₂; NHAlk, where Alk=C₁-C₆, or cycloalkyl-C₃-C₆; NAlk₂, where Alk=C₁-C₆, or cycloalkyl-C₃-C₆; N(CH₂)_n, where n=2, 3, 4, 5, 6; N(CH₂CH₂)₂O; NHAr, where Ar=C₆H₅, C₆H₄R₃, where R₃=Alk(C₁-C₆), NO₂, halide, which can be used as biologically active substances and intermediate products in synthesis of biologically active substances (anomalous nucleosides, nucleotides etc). Sodium salts of 5-NR₁R₂-tetrazolo[1,5-a]-1,3,5-triazin-7-ones are obtained via successive substitution of chlorine atoms in 2-NR₁R₂-4,6-dichloro-1,3,5-triazines with a hydroxy and azido group. The corresponding 2-NR₁R₂-4,6-dichloro-1,3,5-triazine reacts with aqueous sodium hydroxide solution followed by acidation and the obtained 4-NR₁R₂-6-chloro-(3H)-1,3,5-triazin-2-one is treated with sodium azide in an organic solvent such as acetone, acetonitrile, dimethylformamide or mixtures thereof.

EFFECT: obtaining sodium salts of 5-NR₁R₂-tetrazolo[1,5-a]-1,3,5-triazin-7-ones directly from 2-amino-4,6-dichloro-1,3,5-triazines without obtaining and use of bis- and mono-trinitromethyl-1,3,5-triazines.

1 cl, 2 tbl, 3 ex