FIELD: chemistry.
SUBSTANCE: invention relates to biotechnology and immunology. The invention discloses erythropoetin which is conjugated with polyethylene glycol, where polethylene glycol is bonded to erythropoetin via an aromatic azo group.
EFFECT: invention increases circulation time of erythropoetin in blood while preserving its biological activity.
3 cl, 2 dwg, 1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| INTERFERON CONJUGATED WITH POLYETHYLENE GLYCOL | 2010 |
|
RU2433135C1 |
| CONJUGATE OF GLYCOPROTEIN, POSSESSING ERYTHROPOIETIN ACTIVITY, WITH POLY-1,4-ETHYLENEPIPERAZINE N-OXIDE DERIVATIVES (VERSIONS), PHARMACEUTICAL COMPOSITION AND METHOD OF CONJUGATE OBTAINING | 2013 |
|
RU2556378C2 |
| ERYTHROPOETIN APPLICATION | 2003 |
|
RU2305554C2 |
| POLYETHYLENE GLYCOL DERIVATIVES CONTAINING AROMATIC DIAZO GROUP | 2010 |
|
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|
RU2664588C2 |
| HAEMOSTIMULATING MEDICATION | 2010 |
|
RU2437675C1 |
| PHARMACEUTICAL COMPOSITION WITH CYTOKINE AND IMMUNOMODULATING EFFECTS | 2002 |
|
RU2222345C2 |
| TREATMENT OF NEURODEGENERATIVE DISORDERS | 2006 |
|
RU2467761C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING Fc-REGION OF IMMUNOGLOBULIN AS CARRIER | 2004 |
|
RU2352583C2 |
| PROTEIN COMPLEX, OBTAINED BY USING FRAGMENT OF IMMUNOGLOBULIN, AND METHOD OF SUCH COMPLEX OBTAINING | 2004 |
|
RU2356909C2 |
