FIELD: chemistry.
SUBSTANCE: invention relates to field of biotechnology, namely to obtaining conjugates of glycoprotein, possessing erythropoietin activity, with polyethylenepiperazine N-oxide derivatives, and can be used in medicine. Conjugate of erythropoietin, corresponding to general formula (1): [-Ak-Bl-Cm-(D-C(O)-NH-EPO)p-]n, with molecular weight 50-190 kDa is obtained.
EFFECT: invention makes it possible to obtain stable conjugate of erythropoietin, containing biodegradable fragments of poly-1,4-ethylenepiperazine N-oxides, which makes it possible to increase medication safety due to sharp reduction of antigenicity (immunogenicity), toxicity and, therefore, probability of side effects, reduction of frequency of injections and regimen of dosing, as well as provides possibility of carrying out synthesis in water solutions, increase manufacturability, economical efficiency and ecological safety of production.
16 cl, 2 tbl, 9 ex
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