FIELD: pharmaceutical industry.
SUBSTANCE: invention relates to pharmaceutical industry and medicine, in particular to novel PEGylated derivatives of erythropoiesis factors, and concerns the production of novel molecules of conjugates of low-sialylated darbepoetin and polyethylene glycol, possessing erythropoiesis stimulating activity, not resulting in a sharp decline in glucose, with improved pharmacokinetic and pharmacodynamic parameters of general formula (I) or (II).
(I), 
(II).
EFFECT: invention possessing erythropoiesis stimulating activity, not resulting in a sharp decline in glucose, with improved pharmacokinetic and pharmacodynamic parameters.
28 cl, 13 dwg, 21 ex, 6 tbl
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