PREPARATION POTENTIATING RADIATION THERAPY Russian patent published in 2011 - IPC A61K31/513 A61K31/7072 A61P35/00 A61P43/00 C07D403/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to potentiating preparation for radiation therapy, which as effective component contains uracyl derivative, represented by formula (1) where R1 represents halogen atom or cyanogroup; and R2 represents (4-8)-member heterocyclic group, which has from 1 to 3 nitrogen atoms and optinally has as substituent C₁-C₄ alkyl group, iminogroup, hydroxyl group, hydroxymethyl group, methansulphonyloxy group or aminogroup; amidinothiogroup, in which hydrogen atom, bound to nitrogen atom, can be substituted by C₁-C₄ alkyl group; guanidinogroup, in which hydrogen atom, bound to nitrogen atom, can be substituted by C₁-C₄ alkyl group or cyanogroup; C₁-C₄ alkylamidinogroup; or 1-pyrrolidinylmethyl group or its pharmaceutically acceptable salt. Invention also relates to method of radiation therapy potentiation, and to method of cancer treatment, which include introduction of described above uracyl derivative of formula (1) to patient who needs it.

EFFECT: invention ensures reduction of negative effect of radiation therapy, reduction of radiotherapy dose and enhancement of therapeutic effect.

18 cl, 3 tbl, 1 dwg, 4 ex