FIELD: medicine.
SUBSTANCE: group of inventions refers to cancer treatment. Method of treating cancer in a subject in need thereof involves administering to a subject in an effective treatment amount of an antagonist EP4 in combination with a therapy, selected from the group consisting of radiotherapy and therapy with antibodies, is characterized by that the EP4 antagonist is a compound of formula:
or its pharmaceutically acceptable salt. Also disclosed is a method of creating immunological memory for cancer in a subject and another embodiment of a method of treating cancer in a subject.
EFFECT: group of inventions provides effective treatment of solid malignant tumours.
22 cl, 11 dwg, 2 ex
| Title |
Year |
Author |
Number |
| NOVEL APPROACH TO CANCER TREATMENT USING IMMUNOMODULATION |
2016 |
- Mehta, Vimal D.
- Rastelli, Luca
- Sapra, Aparna Katoch
|
RU2817047C2 |
| NEW APPROACH TO TREATING CANCER WITH APPLICATION OF IMMUNOMODULATION |
2016 |
- Mehta, Vimal D.
- Rastelli, Luca
- Sapra, Aparna Katoch
|
RU2711380C2 |
| USE OF EP4 RECEPTOR ANTAGONISTS FOR TREATMENT OF NASH-ASSOCIATED LIVER CANCER |
2017 |
- Ohtani Naoko
- Kamachi Fumitaka
- Loo Tze Mun
- Koizumi Shinichi
- Okumura Takako
|
RU2717331C2 |
| USE OF EP4 RECEPTOR ANTAGONISTS FOR TREATMENT OF NASH-ASSOCIATED LIVER CANCER |
2017 |
- Ohtani, Naoko
- Kamachi, Fumitaka
- Loo, Tze Mun
- Koizumi, Shinichi
- Okumura, Takako
|
RU2762193C2 |
| METHODS AND COMPOSITIONS FOR TUSC2-IMMUNOTHERAPY |
2017 |
|
RU2755903C2 |
| IMPROVED THERAPEUTIC INDEX OF INHIBITORS AGAINST IMMUNE CHECKPOINT USING COMBINATION THERAPY INCLUDING PHY906 EXTRACT, SCUTELLARIA BAICALENSIS GEORGI (S) EXTRACT OR COMPOUND OF SUCH EXTRACTS |
2017 |
- Cheng, Yung-Chi
- Chen, Lieping
|
RU2753523C2 |
| ABX196 FOR USE IN TREATMENT OF BLADDER CANCER |
2018 |
- Crabe, Sandrine
- Scherrer, Didier
- Ehrlich, Hartmut
- Pouletty, Philippe
|
RU2778812C2 |
| COMBINATION THERAPY FOR TREATING CANCER WITH POXVIRUS EXPRESSING TUMOUR ANTIGEN AND ANTAGONIST AND/OR AGONIST OF IMMUNE CHECKPOINT INHIBITOR |
2014 |
- Rauntri, Rajan
- Foj, Syuzan
- Mendl, Stefani
- Delker, Alen
|
RU2714142C2 |
| TREATING CANCER WITH IMMUNOSTIMULANTS |
2015 |
- King, Robert S.
- Tuthill, Cynthia
- Blombel, Friedhelm
|
RU2740288C2 |
| BISPECIFIC ANTIBODIES TO CD25 AND Fc GAMMA-RECEPTOR FOR ELIMINATION OF TUMOR-SPECIFIC CELLS |
2017 |
- Kezada, Serkhio
- Peggs, Karl
- Arse Vargas, Frederik
|
RU2759970C2 |
