HETEROBICYCLIC CARBOXAMIDES AS KINASE INHIBITORS Russian patent published in 2011 - IPC C07D413/12 C07D417/12 C07D417/14 C07D405/12 C07D405/14 C07D409/12 C07D409/14 C07D403/12 C07D403/14 A61K31/506 

FIELD: chemistry.

SUBSTANCE: invention relates to novel organic compounds of formula where R₁ denotes H; halogen; -C₀-C₇-alkyl-O-R₃; -NR₄R₅; R₂ denotes phenyl, substituted with one or two substitutes selected from a group consisting of C_1-7alkyl, halogen-C_1-7alkyl, C_1-7alkoxy, halogen-C_1-7alkoxy, phenoxy, halogen, C_1-7alkylpiperazinyl-C_1-7alkyl, C₃-C₈-cyclalkyl, C_1-7alkylpiperidinyl-C_1-7alkyl and C_1-7alkylimidazolyl; R₃ denotes H or phenyl-lower alkyl; R₄ and R₅ are independently selected from a group consisting of H; lower alkyl; lower alkoxy-carbonyl and amino; A, B and X are independently selected from C(R₇) or N, provided that not more than one or A, B and X denotes N; R₇ denotes H; R₈ denotes hydrogen; n equals 0; Y denotes O; Z denotes C; W is absent; K denotes N or C, and either a) if K denotes C, the bond shown by a wavy line () is a double bond, Q is selected from O-N, S-N, O-CH and S-CH, where in each case, the left-hand O or S atom is bonded through a bond shown in formula I to K, the right-hand N or carbon (CH) atom is bonded to C through a bond shown by a dotted line () in formula I, provided that said bond, which is shown by the dotted line, is a double bond with C; and the bond shown by a thick line () is a single bond; or b) if K denotes N, the bond shown by a wavy line () is a single bond; Q denotes N=CH, where the left-hand N atom is bonded through a bond shown in formula I to K, the right-hand carbon (CH) atom is bonded to C through a bond shown by a dotted line () in formula I, provided that said bond, which is shown by a dotted line, is a single bond with C; and the bond shown by thick line () is a double bond; or salt thereof (preferably pharmaceutically acceptable salt). The invention also relates to a pharmaceutical composition, having inhibiting action on protein kinase, containing a compound of formula I or salt thereof in an effective amount and at least one pharmaceutically acceptable carrier material.

EFFECT: heterocyclic carboxamides as kinase inhibitors.

12 cl, 25 ex