NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION Russian patent published in 2011 - IPC C07D401/12 C07D417/12 C07D403/12 C07D413/14 A61K31/4427 A61K31/497 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of general formula where: R₁ denotes COOR_a1, CONR_a2R_a2', CONR_a4OR_a4', where: each of R_a1 and R_a4 denotes a hydrogen atom; each of R_a2 and R_a2' denotes a hydrogen atom; R_a4' denotes a lower alkyl; or R₁ denotes a heterocyclic group selected from the following groups, where Y₂ denotes a hydrogen atom or a lower alkyl: R₂ denotes O, S, SO, SO₂; R₃ denotes a phenyl which is substituted with 2 substitutes selected from halogen, CF₃; X₂ denotes CH or N; W denotes the following residue: where: W₁ denotes CH or S; W₂ denotes CH; W₃ denotes C or N; and at least one of W₁, W₂ and W₃ denotes a carbon atom; or pharmaceutically acceptable salt or ester thereof. The invention also relates to a pharmaceutical composition having Avrora A selective inhibitory action, which, along with a pharmaceutically acceptable carrier or diluent, contains at least one compound of formula I a an active ingredient.

EFFECT: aminopyridine or aminopyrazine derivatives which inhibit growth of tumour cells based on Avrora A kinase selective inhibitory action.

11 cl, 3 tbl, 24 ex