NEW AMINOPYRIDIN DERIVATIVE WITH INHIBITION ACTIVITY IN RELATION TO SYK Russian patent published in 2009 - IPC C07D409/14 C07D413/14 C07D417/14 A61K31/4436 A61K31/4439 A61K31/444 A61K31/4427 A61K31/4523 A61K31/496 A61K31/506 A61K31/5375 A61P17/00 A61P19/02 A61P25/00 A61P27/02 A61P27/16 A61P29/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: present invention refers to the aminopyridin compound of general formula (I) or its salt wherein X¹, X², X³, Z, Y¹, Y² are carbon or nitrogen atom, R, R¹, R⁵, R⁶ are hydrogen atom, alkyl group, further see formula of the invention, and R⁷ is hydrogen or halogen atom, nitro or cyano group, -C_pH_2(p-1)(R^a1)(R^a2)-O-R^a3, -C(=O)-R^d1, 5-or 6-membered saturated heterocycle group, aromatic heterocycle group, -N(R^h1)(R^h2), further see formula of the invention. The invention refers also to the pharmaceutic composition thereof intended for treatment or prevention of allergic diseases, autoimmune diseases caused by malignant tumour, to the Syk inhibitor containing the compound of formula I and to the therapeutic and/or preventive agent.

EFFECT: compounds which not only possess high Syk inhibition activity but are selective Syk inhibitors are obtained and described.

24 cl, 24 ex, 2 tbl