METHOD FOR PREPARING N-METHYL-N-[(1S)-1-PHENYL-2-((3S)-3-HYDROXYPYRROLIDIN-1-YL)ETHYL]-2,2-DIPHENYLACETAMIDE AS PURE ENANTIOMER Russian patent published in 2007 - IPC C07D207/12 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for synthesis of N-methyl-N-{(1S)-1-phenyl-1-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl}-2,2-diphenylacetamide. Method involves the following steps: (a) interaction of N-substituted derivative of phenylglycine of the formula (I): , wherein R means -OR¹, -SR¹; R¹ means A, benzyl, unsubstituted phenyl or phenyl, biphenyl or naphthyl mono- or disubstituted with halogen atom, -OA or (C₁-C₆)-alkyl; A means linear or branched (C₁-C₆)-alkyl; M means hydrogen atom (H) or a cation chosen from group comprising alkaline metals, earth-alkaline metals, ammonium or alkylammonium with compound of the formula (II): , wherein R² means H, A, or with acid-additive salt of compound of the formula (II) of acids HCl, HBr, HJ, H₂SO₄, H₃PO₄, or with organic carboxylic acid to obtain compound of the formula (III): , wherein R and R² have above given values; (b) synthesized compound is converted to compound of the formula (IV): , by reduction reaction that is converted optionally to acid-additive salt of acids HCl, HBr, HJ, H₂SO₄, H₃PO₄, or to salt of organic carboxylic acid, and (c) synthesized compound of the formula (IV) is subjected for interaction with activated carboxylic acid of the formula (V): , wherein R⁴ means F, Cl, Br, J, -OA or -O-CO-A to yield compound of the formula (VI): , that is converted to a corresponding acid-additive salt using inorganic acid chosen from group comprising HCl, HBr, HJ, sulfuric acid, sulfamic acid, nitric acid, phosphoric acid, ortho-phosphoric acid or using organic acid.

EFFECT: improved method of synthesis.

7 cl, 8 ex