N-METHYL-N-[(1S)-1-PHENYL-2((3S)-3-HYDROXYPYRROLIDINE-1-Y1)-ETHYL]-2,2-DIPHENYLACETAMIDE Russian patent published in 2001 - IPC

Abstract RU 2174976 C2

FIELD: organic chemistry. SUBSTANCE: invention relates to N-methyl-N-[(1S)-1-phenyl-2- ((3S)-3-hydroxypyrrolidine-1-yl)-ethyl] -2,2- diphenylacetamide that can be used in treatment of patients with intestine inflammatory diseases. Compounds is synthesized by interaction of 1-[(1S)-3-hydroxypyrrolidine-1-yl] -(2S)-2-methylamino-2- phenylethane solution cooled from -5 C to 10 C with diphenyl- -acetyl chloride in solvent in molar ratio of the parent reagent from 1:0.75 to 1:1.65, respectively, and in molar ratio of the parent reagents to solvent = (0.8-1.2):(0.9-1.3):(14-22). Crude product synthesized by this reaction is recrystallized in its warm state from solvent. Melting point of synthesized compound is 221-226 C. Compound synthesized by the proposed method is resistant thermodynamically. EFFECT: improved method of synthesis, valuable properties. 2 cl, 10 ex

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RU 2 174 976 C2

Authors

Inge Shtejn

Khol'Ger Beeres

Klaus Beshmann

Shteffen Nojenfel'D

Ehndrju Barber

Dates

2001-10-20—Published

1996-08-23—Filed