2-SUBSTITUTED BENZIMIDAZOLES Russian patent published in 2012 - IPC C07D235/30 C07D401/06 A61K31/4184 A61P31/12 A61P11/00 

FIELD: pharmachology

SUBSTANCE: invention refers to the RSV-replication inhibitors with formula (I) Its additive salts and stereochemically isomeric forms where Q means hydroxy, C_1-4alkyloxy, C_1-4alkylcarbonylamino, C_1-4alkyloxycarbonylamino, carboxyl, C_1-4alkyloxycarbonyl, C_1-4alkylcarbonyl, aminocarbonyl, mono- or di(C1-4alkyl)aminocarbonyl; each Alk is C_1-6alkandiyl; R1 means heterocycle chosen out of pyridyl, pyrazynil, pirydazynil, pyrimidinyl and pyrrolyl; where each of stated heterocycles optionally can be substituted with 1, 2 or 3 substitutes, each of which is independently chosen out of group including hydroxyl, C_1-6alkyl and hydroxyC_1-6alkyl; R² means hydrogen atom; R³ means hydrogen atom; R⁴ means Ar²; Ar² means phenyl substituted with one or several substitutes i.e. 2, 3, 4 or 5 chosen out of halogen, C_1-6alkyl, C_2-6alkenyl, C_2-6alkynyl, N(R^5aR^5b)-sulphonyl, R^5b-O-C_1-6-alkyl, Het, Het-C_1-6alkyl, where Het means morhpolynyl, N(R^5aR^5b)- C_1-6-alkyl, N(R^5aR^5b)-C(=O)-C_1-6-alkyl; R^5a means hydrogen atom; R^5b means hydrogen atom, and also refers to pharmaceutical compositions containing compounds (I) and methods of production of compounds (I).

EFFECT: improved production of medicine.

8 cl, 4 ex, 1 tbl