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(19)

(11)

2 419 613

(13)

(51)

IPC

C07D235/24(2006-01-01)

C07D401/06(2006-01-01)

A61K31/4184(2006-01-01)

A61P31/12(2006-01-01)

A61P11/00(2006-01-01)

(21) (22)

Application

2008102065/04, 2006-06-20

(24)

Start date

2006-06-20

(22)

Actual filing date

2006-06-20

(45)

Published

2011-05-27

(72)

Inventor

Bonfanti Zhan-FransuaMjuller FilippFortehn Zherom Mishel' KlodDuble Frederik Mark Moris

(73)

Holder

Tibotek Farmas'Jutikalz Ltd

HETEROCYCLYLAMINOALKYL-SUBSTITUTED BENZIMIDAZOLES Russian patent published in 2011 - IPC C07D235/24 C07D401/06 A61K31/4184 A61P31/12 A61P11/00

Abstract RU 2419613 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to compounds of formula

, where Q denotes C_1-6alkyl substituted with a heterocycle, selected from oxazolidine, morpholinyl or hexahydrooxazepine; where each of the said heterocycles can be optionally substituted with one or two C_1-6alkyls; each Alk independently denotes C_1-6alkanediyl; R¹ denotes pyridyl, pyrazinyl, pyridazinyl, pyrimidiniyl or pyrrolyl, where each of the said heterocycles may be optionally substituted with 1, 2 or 3 substitutes, independently selected from hydroxy, C_1-6alkyl hydroxy C_1-6alkyl; R² denotes hydrogen; R³ denotes hydroxy C_1-6alkyl; R⁴ denotes hydrogen or C_1-6alkyl; R⁵ denotes hydrogen or C_1-6alkyl; and Het denotes pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl or pyrrolyl. The present invention also relates to a method of producing compounds of formula (I).

EFFECT: obtained compositions, as well as compositions based on said compounds, can inhibit respiratory syncytial virus (RSV) replication.

11 cl, 12 ex, 2 tbl

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RU 2 419 613 C2

Authors

Bonfanti Zhan-Fransua

Mjuller Filipp

Fortehn Zherom Mishel' Klod

Duble Frederik Mark Moris

Dates

2011-05-27—Published

2006-06-20—Filed