PIPERIDINE-AMINO-BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION Russian patent published in 2010 - IPC C07D401/14 C07D417/14 A61K31/4184 A61P11/00 A61P31/12 

FIELD: chemistry.

SUBSTANCE: present invention relates to piperidine-amino-benzidazoles having formula (I) and to addition salts or stereochemically isomeric forms, where Q is C_1-6alkyl optionally substituted with one or two substitutes, each independently selected from a group consisting of trifluoromethyl, C₃-₇cycloalkyl, Ar², hydroxyl, Ar² - oxy-, hydroxycarbonyl, aminocarbonyl, C_1-4alkylcarbonyl, aminocarbonyloxy, C_1-4alkoxycarbonyl, Ar²(CH₂)_ncarbonyloxy, C_1-4alkoxycarbonyl-(CH₂)_noxy, mono- or di(C_1-4alkyl)aminocarbonyl, aminosulfonyl, mono(C_1-4alkyl)aminosulfonyl, or heterocycle selected from a group consisting of pyrrolidinyl, dihydropyrrolyl, imidazolyl, triazolyl, homopiperidinyl, pyridyl and tetrahydropyridyl; or where Q is C_1-6alkyl substituted with two substitutes, where substitute is an amino group and the other is C_1-6alkyloxycarbonyl; G is -CH₂-; R¹ is pyridyl optionally substituted with two substitutes selected from a group consisting of hydroxyl, C_1-6alkyl; each n equals 1; one of R^2a and R^3a is C_1-6alkyl and the other is hydrogen; when R^2a is not hydrogen, R^2b is C_1-6alkyl and R^3b is alkyl; and R^3a, R^2a, R^2b all represent hydrogen; or R⁵ is hydrogen; t equals 2; Ar² is phenyl or phenyl substituted with one or more, for example 2 substitutes selected from halogen, C_1-6alkyloxy, aminosulfonyl and C_1-4alkoxycarbonyl. The invention also relates to a pharmaceutical composition based on compound of formula I and use of the said compounds in making medicinal agents.

EFFECT: novel piperadine-amino-benzimidazoles are obtained, having inhibitory effect on respiratory syncytial virus replication.

10 cl, 3 tbl, 5 ex