FIELD: pharmacology.
SUBSTANCE: invention refers to binuclear nitrosyl iron complexes with benzazeheterocyclic derivatives with general formula [Fe2(SR)2(NO)4] where R is And where X is NH, S, R1 is lower alkyl. Also there is proposed method for its production, nitrogen monoxide donor, application as oncology drug and for production of oncology drug, pharmaceutical composition and set used for treatment of oncology diseased.
EFFECT: production of binuclear nitrosyl iron complex that is used as an oncology drug with increased effectiveness and decreased toxicity.
15 cl, 3 ex, 4 tbl, 3 dwg
Title | Year | Author | Number |
---|---|---|---|
USING TETRANITROSYL COMPLEX OF IRON WITH THIOPHENOL AS ANTI-TUMOUR MEDICINAL AGENT | 2007 |
|
RU2429242C2 |
WATER-SOLUBLE BINUCLEAR CATION NITROSYL IRON COMPLEXES WITH NATURAL ALIPHATIC THIOLYLS POSSESSING CYTOTOXIC, APOPTOTIC AND NO-DONOR ACTIVITY | 2008 |
|
RU2441873C2 |
MONONECLEAR DINITROSYL FERRIC COMPLEXES, METHOD FOR PREPARING MONONECLEAR DINITROSYL FERRIC COMPLEXES, NITROGEN MONOXIDE DONOR, USING MONONECLEAR DINITROSYL FERRIC COMPLEXES AS ANTI-TUMOUR DRUG | 2011 |
|
RU2494104C2 |
SINGLE-NUCLEAR CATIONIC DINITROSYL IRON COMPLEXES, METHOD FOR PRODUCING THEM, NITROGEN MONOXIDE DONOR | 2014 |
|
RU2567245C1 |
USE OF BINUCLEAR SULPHUR-NITROSYL CATIONIC IRON COMPLEX AS VASODILATATOR | 2010 |
|
RU2460531C2 |
SUPRAMOLECULAR ASSEMBLIES OF DINITROSYL IRON COMPLEXES, METHOD OF THEIR PREPARATION, NITROGEN MONOXIDE DONORS, PHOSPHODIESTERASE INHIBITORS, USE OF SUPRAMOLECULAR ASSEMBLIES OF DINITROSYL IRON COMPLEXES AS ANTI-INFLAMMATORY MEDICINAL PRODUCTS | 2023 |
|
RU2814108C1 |
APPLICATION OF BINUCLEAR SULPHUR-NITROSYL COMPLEX OF ANION TYPE IRON AS VASODEPRESSOR MEDICATION | 2010 |
|
RU2437667C1 |
URIDINE PHOSPHORYLASE INHIBITOR | 2012 |
|
RU2522548C2 |
AGENT WITH ANTIVIRAL ACTIVITY AGAINST SARS-COV-2 AND METHOD OF USING THE SAME | 2022 |
|
RU2797619C1 |
SULPHUR-CONTAINING FULLERENE DERIVATIVES AND METHOD FOR PRODUCTION THEREOF | 2011 |
|
RU2477273C2 |
Authors
Dates
2012-02-10—Published
2007-05-30—Filed