FIELD: biochemistry.
SUBSTANCE: invention refers to derivatives of 3'-ethynilcytidine represented by the formula (1); 
(where X is hydrogen atom, alkylcarbonyl group where alkyl fragment is non-branched or branched C1-C6alkyl group which can include as substitute(s) mono-or di-substituted with non-branched or branched C1-C6alkyl group aminogroup or alkoxycarbonyl group where alkoxy-fragment is a branched or non-branched C1-C6 alkoxygroup; One of Y and Z is a hydrogen atom or group (R1)(R2)(R3)Si-, and another is a group (R4)(R5)(R6)Si-; and each R1, R2, R3, R4, R5 and R6 that may be similar or different are non-branched or branched C1-C10 alkyl group or C6-C14aryl group) or to its salts. The invention also refers to the derivative of 3'-ethynilcytidine chosen out of compounds (1)-(17), to the pharmaceutical composition, to oncologic drug, to oral oncologic drug, to the use of derivative of 3'-ethynilcytidine, and to the method of tumor treatment.
EFFECT: new biologically active compounds with antitumor activity.
14 cl, 18 ex, 12 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED DERIVATIVES OF NUCLEOSIDE, A METHOD OF THEIR SYNTHESIS (VARIANTS), A DRUG, A METHOD OF TREATMENT AND PROPHYLAXIS | 1995 |
|
RU2130029C1 |
| NOVEL PYRIMIDINE NUCLEOSIDE OR SALT THEREOF | 2006 |
|
RU2395517C2 |
| COMPLEXES | 2015 |
|
RU2682680C2 |
| PHOSPHOINDOLES AS HIV INHIBITORS | 2005 |
|
RU2393163C2 |
| METHODS OF PRODUCING 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND DERIVATIVES THEREOF | 2005 |
|
RU2433124C2 |
| PYRIMIDINE NUCLEOSIDES, METHODS OF SYNTHESIS, PHARMACEUTICAL COMPOSITION | 1991 |
|
RU2116306C1 |
| COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VIRAL INFECTIONS | 2007 |
|
RU2466729C2 |
| COMPLEXES | 2015 |
|
RU2684934C2 |
| COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VIRAL INFECTIONS | 2007 |
|
RU2525392C2 |
| DERIVATIVES OF 5'-DEOXYCYTIDINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF | 1998 |
|
RU2238278C2 |
